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Scored tablet containing 25 mg of Pregnenolone for hormonal support. Tablets can be dissolved in mouth and swallowed or swallowed whole. Pregnenolone is a steroid hormone that plays a key role in the production of other steroid hormones, including progesterone, DHEA, and estrogen.‡ Pregnenolone FAQs What is Pregnenolone? Pregnenolone is a hormone naturally produced in the body by the adrenal gland. It is also made from cholesterol, and used as a chemical starting material in the production of testosterone, progesterone, cortisol, estrogen, and other key hormones. Why is Pregnenolone Used? Interest in pregnenolone as an anti-aging compound, for hormone replacement and to treat a broad spectrum of medical conditions has been ongoing for decades. Pregnenolone is a precursor in the biosynthesis of other hormones, and it is sometimes advertised to boost the production of other hormones or to improve one's overall health. What Time of Day Should I Take Pregnenolone? Pregnenolone is a powerful steroid hormone that acts to reduce the effects of stress on the body. Take as indicated per day with a meal in the morning or early afternoon‚ preferably on an empty stomach. For best results, take it in the morning. How Long Does It Take for Pregnenolone to Work? Most nutritional supplements require 3 to 4 months to reach peak effectiveness and produce the best results. This is because it can take time for the dietary supplement to correct the levels of hormones already in your body. Will Pregnenolone Help You Sleep? Pregnenolone, an endocrine hormone produced by the human body, has been shown to improve sleep quality, which may alleviate fatigue and correct sleep disturbance disorders such as insomnia or inability to fall asleep. Is Pregnenolone an Anti-Inflammatory? Pregnenolone acts as a precursor for other steroid hormones and also itself functions as an anti-inflammatory molecule in immune conditions. It does so by maintaining immune homeostasis. What Causes Low Pregnenolone?